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Rosuvastatin and Vascular Events in Patients with Elevated C-Reactive Protein
17,802 healthy men and women with LDL cholesterol levels of less than 130 mg per deciliter and high-sensitivity CRP levels of 2.0 mg per liter or more were treated with rosuvastatin or placebo. The incidence of major cardiovascular events was significantly lower in the rosuvastatin group.
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Published Online November 9, 2008 (DOI: 10.1056/NEJMoa0807646)
The JUPITER Trial: Will You Change Your Practice?
Take a poll about this trial and contribute your comments.
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Genotype Score and Prediction of Diabetes
In this study, a genotype score based on 18 diabetes-associated loci predicted new cases of diabetes but resulted in only a slightly better prediction of risk than knowledge of common risk factors alone.
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Clinical Risk Factors, DNA Variants, and Diabetes
Sixteen SNPs were determined and clinical factors examined in two Scandinavian cohorts that were followed for a median of 23.5 years. Type 2 diabetes developed in 11.7 percent of the subjects.
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Early Antiretroviral Therapy and Mortality among HIV-Infected Infants
In this randomized trial involving 377 HIV-infected infants in South Africa, early initiation of antiretroviral therapy reduced infant mortality by 76 percent and the rate of HIV progression by 75 percent.
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CME Exam
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ICDs after Myocardial Infarction
The authors discuss which patients with a history of myocardial infarction and a reduced ejection fraction are the most appropriate candidates for implantable cardioverter–defibrillator (ICD) therapy.
CME Exam
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Pulmonary Complications of Sickle Cell Disease
This review focuses on the acute vaso-occlusive crisis, the acute chest syndrome, and pulmonary hypertension, all common complications of sickle cell disease.
CME Exam
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Peripheral Intravenous Cannulation
The ability to obtain peripheral intravenous access is an essential and potentially lifesaving skill for all physicians. This video demonstrates how to cannulate peripheral veins with the use of an intravenous catheter.
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A Man with Chronic Daily Headache
A 59-year-old man was admitted to the hospital with a 6-month history of chronic daily headache, fever, and myalgia. Neuroimaging studies showed diffuse thickening and enhancement of the dura, extending to the pituitary stalk. Computed tomography revealed calcified nodules in the lungs and spleen.
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Codon Switching to Attenuate Viral Replication
A proof-of-principle study shows that attenuation of a virus can be achieved by interfering with codon-pair bias. The modified virus encodes an amino acid sequence that is identical to that of wild-type virus but is probably translated less efficiently.
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South Dakota’s Abortion Script
Under a new law, physicians in South Dakota must tell any woman seeking an abortion that she is terminating the life of “a whole, separate, unique, living human being.” Zita Lazzarini argues that these provisions mark a substantial inroad into the physician–patient relationship — one that ought to worry any practicing physician.
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Related Editorial: Physicians and the First Amendment
 November 19, 2008 (DOI: 10.1056/NEJMe0809669), in Print December 4, 2008
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The Genetic Privacy of Presidential Candidates
Advances in genomics make it more likely that in the next presidential campaign, DNA will be collected and analyzed to assess genetic risk information that could be used against presidential candidates. Dr. Robert Green and George Annas argue that using genetic information to disparage opponents has no place in presidential campaigns.
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Expanding the Orbit of Primary Prevention — Moving
beyond JUPITER Free Full Text
Published Online November 9, 2008 (DOI: 10.1056/NEJMe0808320)
Cyclosporine in Acute Myocardial Infarction
Quality of Life with PCI vs. Medical Therapy in Stable Coronary Disease
Malaria Prevention in Short-Term Travelers Free Full Text
The FDA and Tobacco Regulation Free Full Text
Restless Legs Syndrome and Spinal Anesthesia
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Recurrent Aspiration Pneumonia
An 84-year-old man was admitted to the hospital because of a decrease in mental status, profound hyponatremia, questionable lung infiltrates, and difficulty swallowing. A barium-swallow examination was performed.
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The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. Material is published with an emphasis on internal medicine and specialty areas including allergy/immunology, cardiology, endocrinology, gastroenterology, hematology, kidney disease, oncology, pulmonary disease, rheumatology, HIV, and infectious diseases.
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